The story of a Ronin (i.e. a masterless samurai) who wanders the countryside of Japan with his small child, having various adventures.
Trailed by a clan of female ninja, Ogami is paid to assassinate a clan traitor accompanied by three killers known as the Gods of Death.
Ogami Itto volunteers to be tortured by the yakuza to save a prostitute and is hired by their leader to kill an evil chamberlain.
Ogami is hired to kill a tattooed female assassin. Gunbei Yagyu, an enemy samurai, happens upon Ogami's son, and sees his chance for revenge.
Five warriors challenge Ogami to duels. Each holds a part of information needed to complete the assassination of a mad clan leader.
In the sixth and final film of the Lone Wolf and Cub series, the final conflict between Ogami Itto and the Yagyu clan is carried out.
